Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Patricia L. Andres; Margaret Peggy Allred; Helen E. Stephens; Mary Proffitt Bunnell; Catherine Siener; Eric A. Macklin; Travis Haines; Robert A. English; Katherine A. Fetterman; Edward J. Kasarskis; Julaine Florence; Zachary Simmons; Merit E. Cudkowicz

doi:10.1002/mus.25586

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Patricia L. Andres, Margaret Peggy Allred, Helen E. Stephens, Mary Proffitt Bunnell, Catherine Siener, Eric A. Macklin, Travis Haines, Robert A. English, Katherine A. Fetterman, Edward J. Kasarskis, Julaine Florence, Zachary Simmons, Merit E. Cudkowicz

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017.

Original language	English
Pages (from-to)	710-715
Number of pages	6
Journal	Muscle and Nerve
Volume	56
Issue number	4
DOIs	https://doi.org/10.1002/mus.25586
State	Published - Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Keywords

ALS
ALSFRS-R
longitudinal
outcome measure
strength
vital capacity

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

Access to Document

10.1002/mus.25586

Cite this

@article{76651ad84f4e4ae0a8fcbc25838e289f,

title = "Fixed dynamometry is more sensitive than vital capacity or ALS rating scale",

abstract = "Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017.",

keywords = "ALS, ALSFRS-R, longitudinal, outcome measure, strength, vital capacity",

author = "Andres, {Patricia L.} and Allred, {Margaret Peggy} and Stephens, {Helen E.} and {Proffitt Bunnell}, Mary and Catherine Siener and Macklin, {Eric A.} and Travis Haines and English, {Robert A.} and Fetterman, {Katherine A.} and Kasarskis, {Edward J.} and Julaine Florence and Zachary Simmons and Cudkowicz, {Merit E.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2017",

month = oct,

doi = "10.1002/mus.25586",

language = "English",

volume = "56",

pages = "710--715",

number = "4",

}

TY - JOUR

T1 - Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

AU - Andres, Patricia L.

AU - Allred, Margaret Peggy

AU - Stephens, Helen E.

AU - Proffitt Bunnell, Mary

AU - Siener, Catherine

AU - Macklin, Eric A.

AU - Haines, Travis

AU - English, Robert A.

AU - Fetterman, Katherine A.

AU - Kasarskis, Edward J.

AU - Florence, Julaine

AU - Simmons, Zachary

AU - Cudkowicz, Merit E.

PY - 2017/10

Y1 - 2017/10

N2 - Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017.

AB - Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017.

KW - ALS

KW - ALSFRS-R

KW - longitudinal

KW - outcome measure

KW - strength

KW - vital capacity

UR - http://www.scopus.com/inward/record.url?scp=85016485344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016485344&partnerID=8YFLogxK

U2 - 10.1002/mus.25586

DO - 10.1002/mus.25586

M3 - Article

C2 - 28120413

AN - SCOPUS:85016485344

SN - 0148-639X

VL - 56

SP - 710

EP - 715

JO - Muscle and Nerve

JF - Muscle and Nerve

IS - 4

ER -

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this