FKBP51 and the molecular chaperoning of metabolism

Kathryn B. Smedlund; Edwin R. Sanchez; Terry D. Hinds

doi:10.1016/j.tem.2021.08.003

FKBP51 and the molecular chaperoning of metabolism

Kathryn B. Smedlund, Edwin R. Sanchez, Terry D. Hinds

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

Original language	English
Pages (from-to)	862-874
Number of pages	13
Journal	Trends in Endocrinology and Metabolism
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.tem.2021.08.003
State	Published - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Funding

This work was supported by grants R01DK121797 (T.D.H.) and R01DK121017 (E.R.S.) from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Matthew Hazzard at the University of Kentucky College of Medicine for the development of the graphical illustrations in Figures 2 and 3. No interests are declared. This work was supported by grants R01DK121797 (T.D.H.) and R01DK121017 (E.R.S.) from the National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Matthew Hazzard at the University of Kentucky College of Medicine for the development of the graphical illustrations in Figures 2 and 3 .

Funders	Funder number
University of Kentucky College of Medicine
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK121797, R01DK121017

Keywords

AKT
FKBP4
FKBP5
adipose
diabetes
obesity

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2021.08.003

Cite this

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title = "FKBP51 and the molecular chaperoning of metabolism",

abstract = "The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.",

keywords = "AKT, FKBP4, FKBP5, adipose, diabetes, obesity",

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year = "2021",

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doi = "10.1016/j.tem.2021.08.003",

language = "English",

volume = "32",

pages = "862--874",

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AU - Smedlund, Kathryn B.

AU - Sanchez, Edwin R.

AU - Hinds, Terry D.

PY - 2021/11

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N2 - The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

AB - The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

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KW - FKBP4

KW - FKBP5

KW - adipose

KW - diabetes

KW - obesity

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DO - 10.1016/j.tem.2021.08.003

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FKBP51 and the molecular chaperoning of metabolism

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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