FKBP51 and the molecular chaperoning of metabolism

Kathryn B. Smedlund, Edwin R. Sanchez, Terry D. Hinds

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

Original languageEnglish
Pages (from-to)862-874
Number of pages13
JournalTrends in Endocrinology and Metabolism
Volume32
Issue number11
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported by grants R01DK121797 (T.D.H.) and R01DK121017 (E.R.S.) from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Matthew Hazzard at the University of Kentucky College of Medicine for the development of the graphical illustrations in Figures 2 and 3. No interests are declared.

Funding Information:
This work was supported by grants R01DK121797 (T.D.H.) and R01DK121017 (E.R.S.) from the National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Matthew Hazzard at the University of Kentucky College of Medicine for the development of the graphical illustrations in Figures 2 and 3 .

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • AKT
  • FKBP4
  • FKBP5
  • adipose
  • diabetes
  • obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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