Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot

Damodar Pokhrel, Lana Sanford, Bhaswanth Dhanireddy, Janelle Molloy, Marcus Randall, Ronald C. McGarry

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Cone-beam CT-guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X-FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow-up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow-up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalJournal of Applied Clinical Medical Physics
Issue number4
StatePublished - Apr 1 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.


  • FFF-beam
  • VMAT
  • beam-on time
  • outcomes
  • single dose
  • stereotactic lung treatment

ASJC Scopus subject areas

  • Radiation
  • Instrumentation
  • Radiology Nuclear Medicine and imaging


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