Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot

Damodar Pokhrel; Lana Sanford; Bhaswanth Dhanireddy; Janelle Molloy; Marcus Randall; Ronald C. McGarry

doi:10.1002/acm2.12829

Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot

Damodar Pokhrel, Lana Sanford, Bhaswanth Dhanireddy, Janelle Molloy, Marcus Randall, Ronald C. McGarry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cone-beam CT-guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X-FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow-up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow-up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.

Original language	English
Pages (from-to)	6-12
Number of pages	7
Journal	Journal of Applied Clinical Medical Physics
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/acm2.12829
State	Published - Apr 1 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Keywords

FFF-beam
VMAT
beam-on time
outcomes
single dose
stereotactic lung treatment

ASJC Scopus subject areas

Radiation
Instrumentation
Radiology Nuclear Medicine and imaging

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10.1002/acm2.12829

Cite this

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title = "Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot",

abstract = "Cone-beam CT-guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X-FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow-up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow-up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.",

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AU - Sanford, Lana

AU - Dhanireddy, Bhaswanth

AU - Molloy, Janelle

AU - Randall, Marcus

AU - McGarry, Ronald C.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Cone-beam CT-guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X-FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow-up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow-up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.

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Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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