Flavonoid adsorption and stability on titania-functionalized silica nanoparticles

Daniel M. Schlipf; Cory A. Jones; Marie E. Armbruster; Elliott S. Rushing; Kaitlyn C. Wooten; Stephen E. Rankin; Barbara L. Knutson

doi:10.1016/j.colsurfa.2015.03.039

Flavonoid adsorption and stability on titania-functionalized silica nanoparticles

Daniel M. Schlipf, Cory A. Jones, Marie E. Armbruster, Elliott S. Rushing, Kaitlyn C. Wooten, Stephen E. Rankin, Barbara L. Knutson

Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The interaction of flavonoids with silica surfaces is of interest for separation and recovery of these natural products with potential anti-oxidant and anti-inflammatory properties. The benefit of tailored silica materials for natural product separation is based on the ability to readily tune their surface functionality and pore structure. In this work, the adsorption of quercetin, a model plant-derived flavonoid, was measured on silica particles (450nm diameter) that were non-functionalized, hydrophobically functionalized (16.2mg decyl groups/g) or titania modified (0.33-9.83mg TiO₂/g). Quercetin interactions with these functionalized silica particles were interpreted from adsorption measurements on non-porous silica particles, which eliminate the potential diffusional and steric constraints of pores. Titania functionalized particles are found to exhibit significantly increased adsorption capacities compared to non-functionalized and decyl functionalized materials, presumably due to binding of quercetin to the metal oxide, and this capacity increased linearly with surface coverage of titania. The ability to recover the activity of bound quercetin is demonstrated using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This investigation provides guidelines for the surface modification of both porous and nonporous silica for the recovery of natural product flavonoids, taking advantage of the binding properties of the functionalized silica surface.

Original language	English
Pages (from-to)	15-21
Number of pages	7
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	478
DOIs	https://doi.org/10.1016/j.colsurfa.2015.03.039
State	Published - Aug 5 2015

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation Integrated Graduate Education and Research Training (IGERT) program on Bioactive Interfaces and Devices (grant # DGE-0653710 ), the University of Kentucky Research Experience for Undergraduates (REU) program # EC-0851716 and a United States Department of Agriculture Biomass Research and Development Initiative (BRDI) grant (award # 2011-10006-30363 ). We would like to thank Eric C. Price for his experimental assistance in lab during his independent study in chemical engineering. We would also like the thank Dr. Kim Anderson for use of her dynamic light scattering particle size analyzer. Thanks to Prachi Gupta and Sundar Prasanth in Dr. Thomas Dziubla's lab at the University of Kentucky for their helpful discussions regarding quercetin, its antioxidant activity and properties in solution.

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

Adsorption
Functionalization
Nano-harvesting
Nanoparticles
Titanosilicates

ASJC Scopus subject areas

Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/j.colsurfa.2015.03.039

Cite this

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title = "Flavonoid adsorption and stability on titania-functionalized silica nanoparticles",

abstract = "The interaction of flavonoids with silica surfaces is of interest for separation and recovery of these natural products with potential anti-oxidant and anti-inflammatory properties. The benefit of tailored silica materials for natural product separation is based on the ability to readily tune their surface functionality and pore structure. In this work, the adsorption of quercetin, a model plant-derived flavonoid, was measured on silica particles (450nm diameter) that were non-functionalized, hydrophobically functionalized (16.2mg decyl groups/g) or titania modified (0.33-9.83mg TiO2/g). Quercetin interactions with these functionalized silica particles were interpreted from adsorption measurements on non-porous silica particles, which eliminate the potential diffusional and steric constraints of pores. Titania functionalized particles are found to exhibit significantly increased adsorption capacities compared to non-functionalized and decyl functionalized materials, presumably due to binding of quercetin to the metal oxide, and this capacity increased linearly with surface coverage of titania. The ability to recover the activity of bound quercetin is demonstrated using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This investigation provides guidelines for the surface modification of both porous and nonporous silica for the recovery of natural product flavonoids, taking advantage of the binding properties of the functionalized silica surface.",

keywords = "Adsorption, Functionalization, Nano-harvesting, Nanoparticles, Titanosilicates",

author = "Schlipf, {Daniel M.} and Jones, {Cory A.} and Armbruster, {Marie E.} and Rushing, {Elliott S.} and Wooten, {Kaitlyn C.} and Rankin, {Stephen E.} and Knutson, {Barbara L.}",

note = "Funding Information: This work was supported by the National Science Foundation Integrated Graduate Education and Research Training (IGERT) program on Bioactive Interfaces and Devices (grant # DGE-0653710 ), the University of Kentucky Research Experience for Undergraduates (REU) program # EC-0851716 and a United States Department of Agriculture Biomass Research and Development Initiative (BRDI) grant (award # 2011-10006-30363 ). We would like to thank Eric C. Price for his experimental assistance in lab during his independent study in chemical engineering. We would also like the thank Dr. Kim Anderson for use of her dynamic light scattering particle size analyzer. Thanks to Prachi Gupta and Sundar Prasanth in Dr. Thomas Dziubla's lab at the University of Kentucky for their helpful discussions regarding quercetin, its antioxidant activity and properties in solution. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = aug,

day = "5",

doi = "10.1016/j.colsurfa.2015.03.039",

language = "English",

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T1 - Flavonoid adsorption and stability on titania-functionalized silica nanoparticles

AU - Schlipf, Daniel M.

AU - Jones, Cory A.

AU - Armbruster, Marie E.

AU - Rushing, Elliott S.

AU - Wooten, Kaitlyn C.

AU - Rankin, Stephen E.

AU - Knutson, Barbara L.

N1 - Funding Information: This work was supported by the National Science Foundation Integrated Graduate Education and Research Training (IGERT) program on Bioactive Interfaces and Devices (grant # DGE-0653710 ), the University of Kentucky Research Experience for Undergraduates (REU) program # EC-0851716 and a United States Department of Agriculture Biomass Research and Development Initiative (BRDI) grant (award # 2011-10006-30363 ). We would like to thank Eric C. Price for his experimental assistance in lab during his independent study in chemical engineering. We would also like the thank Dr. Kim Anderson for use of her dynamic light scattering particle size analyzer. Thanks to Prachi Gupta and Sundar Prasanth in Dr. Thomas Dziubla's lab at the University of Kentucky for their helpful discussions regarding quercetin, its antioxidant activity and properties in solution. Publisher Copyright: © 2015 Elsevier B.V.

PY - 2015/8/5

Y1 - 2015/8/5

N2 - The interaction of flavonoids with silica surfaces is of interest for separation and recovery of these natural products with potential anti-oxidant and anti-inflammatory properties. The benefit of tailored silica materials for natural product separation is based on the ability to readily tune their surface functionality and pore structure. In this work, the adsorption of quercetin, a model plant-derived flavonoid, was measured on silica particles (450nm diameter) that were non-functionalized, hydrophobically functionalized (16.2mg decyl groups/g) or titania modified (0.33-9.83mg TiO2/g). Quercetin interactions with these functionalized silica particles were interpreted from adsorption measurements on non-porous silica particles, which eliminate the potential diffusional and steric constraints of pores. Titania functionalized particles are found to exhibit significantly increased adsorption capacities compared to non-functionalized and decyl functionalized materials, presumably due to binding of quercetin to the metal oxide, and this capacity increased linearly with surface coverage of titania. The ability to recover the activity of bound quercetin is demonstrated using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This investigation provides guidelines for the surface modification of both porous and nonporous silica for the recovery of natural product flavonoids, taking advantage of the binding properties of the functionalized silica surface.

AB - The interaction of flavonoids with silica surfaces is of interest for separation and recovery of these natural products with potential anti-oxidant and anti-inflammatory properties. The benefit of tailored silica materials for natural product separation is based on the ability to readily tune their surface functionality and pore structure. In this work, the adsorption of quercetin, a model plant-derived flavonoid, was measured on silica particles (450nm diameter) that were non-functionalized, hydrophobically functionalized (16.2mg decyl groups/g) or titania modified (0.33-9.83mg TiO2/g). Quercetin interactions with these functionalized silica particles were interpreted from adsorption measurements on non-porous silica particles, which eliminate the potential diffusional and steric constraints of pores. Titania functionalized particles are found to exhibit significantly increased adsorption capacities compared to non-functionalized and decyl functionalized materials, presumably due to binding of quercetin to the metal oxide, and this capacity increased linearly with surface coverage of titania. The ability to recover the activity of bound quercetin is demonstrated using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This investigation provides guidelines for the surface modification of both porous and nonporous silica for the recovery of natural product flavonoids, taking advantage of the binding properties of the functionalized silica surface.

KW - Adsorption

KW - Functionalization

KW - Nano-harvesting

KW - Nanoparticles

KW - Titanosilicates

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Flavonoid adsorption and stability on titania-functionalized silica nanoparticles

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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