Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships

Peter L. Katavic; Kenneth Lamb; Hernan Navarro; Thomas E. Prisinzano

doi:10.1021/np070194x

Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships

Peter L. Katavic, Kenneth Lamb, Hernan Navarro, Thomas E. Prisinzano

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.

Original language	English
Pages (from-to)	1278-1282
Number of pages	5
Journal	Journal of Natural Products
Volume	70
Issue number	8
DOIs	https://doi.org/10.1021/np070194x
State	Published - Aug 2007

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np070194x

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abstract = "Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.",

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Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships

Abstract

ASJC Scopus subject areas

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