Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships

Peter L. Katavic, Kenneth Lamb, Hernan Navarro, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.

Original languageEnglish
Pages (from-to)1278-1282
Number of pages5
JournalJournal of Natural Products
Volume70
Issue number8
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships'. Together they form a unique fingerprint.

Cite this