Abstract
Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 1278-1282 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 70 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2007 |
Funding
| Funders | Funder number |
|---|---|
| National Center for Complementary and Integrative Health | P50AT004155 |
| National Center for Complementary and Integrative Health |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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