TY - JOUR
T1 - Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene
AU - Owens, Elizabeth Oesterling
AU - Toborek, Michal
AU - Hennig, Bernhard
PY - 2009/7
Y1 - 2009/7
N2 - Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4' B-ring hydroxyl substitution and a 2-3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.
AB - Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4' B-ring hydroxyl substitution and a 2-3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.
KW - Atherosclerosis
KW - Benzo[a]pyrene
KW - Flavonoids
KW - Intercellular adhesion molecule-1
UR - http://www.scopus.com/inward/record.url?scp=67349131179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349131179&partnerID=8YFLogxK
U2 - 10.1007/s00128-009-9664-1
DO - 10.1007/s00128-009-9664-1
M3 - Article
C2 - 19214356
AN - SCOPUS:67349131179
SN - 0007-4861
VL - 83
SP - 4
EP - 7
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
IS - 1
ER -