Fluoride nephropathy: lack of direct involvement of renal ATPase

T. Tobin, T. Akera, J. Z. Dworin, T. M. Brody

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2 Scopus citations


A dose related fluoride or methoxyflurane dependent nephropathy has been demonstrated in Fisher 344 rats, which appears related to methoxyflurane nephropathy in man. Since the fluoride ion inhibits Na+ + K+ ATPase, the possibility of direct involvement of renal ATPase in this syndrome was investigated. Fluoride inhibited rat kidney Na+ + K+ ATPase in vitro in the presence of Na+ and ATP and the inhibition produced in this way was stable under conditions used for preparation of this enzyme. However, when sodium fluoride was given subcutaneously to Fisher 344 rats, their urinary output increased fivefold without any significant changes in renal Na+ + K+ ATPase or Mg2+ ATPase activity. These results appear to rule out a direct irreversible action of fluoride on renal Na+ + K+ ATPase or Mg2+ ATPase activity as a mechanism of fluoride or methoxyflurane nephropathy. An indirect action of fluoride on Na+ transport, by limiting the supply of glycolytic energy to the pump, remains likely.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Issue number3
StatePublished - 1974

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)


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