Fluorinated N,N'-diarylureas as novel therapeutic agents against cancer stem cells

Dasha E. Kenlan, Piotr Rychahou, Vitaliy M. Sviripa, Heidi L. Weiss, Chunming Liu, David S. Watt, B. Mark Evers

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Colorectal cancer is the second-leading cause of cancer-related mortality in the United States. More than 50% of patients with colorectal cancer will develop local recurrence or distant organ metastasis. Cancer stem cells play a major role in the survival and metastasis of cancer cells. In this study, we examined the effects of novel AMP-activated protein kinase (AMPK) activating compounds on colorectal cancer metastatic and stem cell lines as potential candidates for chemotherapy. We found that activation of AMPK by all fluorinated N,N-diarylureas (FND) compounds at micromolar levels significantly inhibited the cell-cycle progression and subsequent cellular proliferation. In addition, we demonstrated that select FNDs significantly increased apoptosis in colorectal cancer metastatic and cancer stem cells. Therefore, FNDs hold considerable promise in the treatment of metastatic colorectal cancer, through elimination of both regular cancer cells and cancer stem cells.

Original languageEnglish
Pages (from-to)831-837
Number of pages7
JournalMolecular Cancer Therapeutics
Issue number5
StatePublished - May 1 2017

Bibliographical note

Publisher Copyright:
© 2017 AACR.

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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