TY - JOUR
T1 - Food deprivation and methadone effects on fixed-interval performance by pigeons
AU - Kelly, T. H.
AU - Thompson, T.
PY - 1988
Y1 - 1988
N2 - Five adult male White Carneaux pigeons, maintained at approximately 70, 80 or 90% free-feeding weight, were administered methadone (0.5, 1.5, and 2.5 mg/kg) prior to sessions of key pecking maintained under 5-min fixed-interval schedules of food presentation. Increasing deprivation levels attenuated the rate-decreasing effects of methadone. Methadone effects on pause time were unchanged. Three pigeons, maintained at 80% free-feeding weight were then administered methadone hydrochloride (0.62, 1.25, and 2.5 mg/kg) and naloxone hydrochloride (.0001, .0003, .001, .003 or .01 mg/kg) alone and in combination while responding under these same contingencies. Naloxone had no systematic behavioral effects alone but antagonized methadone's effects on fixed-interval responding and pausing. Naloxone also altered methadone's rate-dependent effects. These results suggest the behavioral effects of methadone are differentially altered following food-deprivation and opiate antagonist manipulations.
AB - Five adult male White Carneaux pigeons, maintained at approximately 70, 80 or 90% free-feeding weight, were administered methadone (0.5, 1.5, and 2.5 mg/kg) prior to sessions of key pecking maintained under 5-min fixed-interval schedules of food presentation. Increasing deprivation levels attenuated the rate-decreasing effects of methadone. Methadone effects on pause time were unchanged. Three pigeons, maintained at 80% free-feeding weight were then administered methadone hydrochloride (0.62, 1.25, and 2.5 mg/kg) and naloxone hydrochloride (.0001, .0003, .001, .003 or .01 mg/kg) alone and in combination while responding under these same contingencies. Naloxone had no systematic behavioral effects alone but antagonized methadone's effects on fixed-interval responding and pausing. Naloxone also altered methadone's rate-dependent effects. These results suggest the behavioral effects of methadone are differentially altered following food-deprivation and opiate antagonist manipulations.
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M3 - Article
C2 - 3421777
AN - SCOPUS:0023884636
SN - 0003-9780
VL - 293
SP - 20
EP - 36
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
IS - 1
ER -