TY - JOUR
T1 - Formation and stability of G-quadruplexes self-assembled from guanine-rich strands
AU - Zhou, Jiang
AU - Yuan, Gu
AU - Liu, Junjun
AU - Zhan, Chang Guo
PY - 2007
Y1 - 2007
N2 - Electrospray ionization mass spectrometry (ESI-MS) was utilized to investigate the formation and stability of G-quadruplexes. For the 15 6-nt oligonucleotides tested, ESI-MS indicated that formation of a parallel tetramer quadruplex requires at least four continuous guanines in the 6-nt sequence. In addition, the G-rich strands prefer to employ "self-association" in the formation of the G-quadruplex rather than hybridized integration, and the thermodynamic-stability order of these three G-quadruplexes is Q(2) > Q(1) > Q(3).
AB - Electrospray ionization mass spectrometry (ESI-MS) was utilized to investigate the formation and stability of G-quadruplexes. For the 15 6-nt oligonucleotides tested, ESI-MS indicated that formation of a parallel tetramer quadruplex requires at least four continuous guanines in the 6-nt sequence. In addition, the G-rich strands prefer to employ "self-association" in the formation of the G-quadruplex rather than hybridized integration, and the thermodynamic-stability order of these three G-quadruplexes is Q(2) > Q(1) > Q(3).
KW - DNA
KW - G-quadruplexes
KW - Polyamides
KW - Self-assembly
KW - Telomeric DNA
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U2 - 10.1002/chem.200600424
DO - 10.1002/chem.200600424
M3 - Article
C2 - 17036297
AN - SCOPUS:33846410277
SN - 0947-6539
VL - 13
SP - 945
EP - 949
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 3
ER -