Abstract
Electrospray ionization mass spectrometry (ESI-MS) was utilized to investigate the formation and stability of G-quadruplexes. For the 15 6-nt oligonucleotides tested, ESI-MS indicated that formation of a parallel tetramer quadruplex requires at least four continuous guanines in the 6-nt sequence. In addition, the G-rich strands prefer to employ "self-association" in the formation of the G-quadruplex rather than hybridized integration, and the thermodynamic-stability order of these three G-quadruplexes is Q(2) > Q(1) > Q(3).
| Original language | English |
|---|---|
| Pages (from-to) | 945-949 |
| Number of pages | 5 |
| Journal | Chemistry - A European Journal |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2007 |
Keywords
- DNA
- G-quadruplexes
- Polyamides
- Self-assembly
- Telomeric DNA
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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