Abstract
A photoactive C-7 derivative of forskolin, [125I]-7-forskolinyl 2-(3-azido-5-hydroxy-4-iodophenoxy)acetate, enhanced GTP-promoted tubulin polymerization, preferentially bound the β-subunit, exhibited competition with the noniodinated version of the probe, and displayed saturation of labeling consistent with the presence of a forskolin binding site or sites on tubulin.
Original language | English |
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Pages (from-to) | 268-274 |
Number of pages | 7 |
Journal | Bioconjugate Chemistry |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1 1993 |
Bibliographical note
Funding Information:We thank the National Institutes of Health (HL 20780) for their generous financial support.
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry