Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

W. R. Markesbery, M. A. Lovell

Research output: Contribution to journalArticlepeer-review

606 Scopus citations


Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalNeurobiology of Aging
Issue number1
StatePublished - Jan 1998

Bibliographical note

Funding Information:
The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason, Cecil Runyons, and Brian Hallahan for technical assistance. This work was supported by the National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.


  • Alzheimer's disease
  • Brain
  • Four-hydroxynonenal
  • Lipid peroxidation
  • Oxidative stress

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


Dive into the research topics of 'Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this