Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

W. R. Markesbery; M. A. Lovell

doi:10.1016/S0197-4580(98)00009-8

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

W. R. Markesbery
, M. A. Lovell

Research output: Contribution to journal › Article › peer-review

622 Scopus citations

Abstract

Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Neurobiology of Aging
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/S0197-4580(98)00009-8
State	Published - Jan 1998

Bibliographical note

Funding Information:
The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason, Cecil Runyons, and Brian Hallahan for technical assistance. This work was supported by the National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

Funding

The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason, Cecil Runyons, and Brian Hallahan for technical assistance. This work was supported by the National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

Funders	Funder number
National Institutes of Health/National Institute of Environmental Health Sciences	1-P01-AG05119, 5-P50-AG05144
National Institute on Aging	P01AG005119
National Institute on Aging
Abercrombie Foundation

Keywords

Alzheimer's disease
Brain
Four-hydroxynonenal
Lipid peroxidation
Oxidative stress

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/S0197-4580(98)00009-8

Cite this

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title = "Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease",

abstract = "Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.",

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author = "Markesbery, \{W. R.\} and Lovell, \{M. A.\}",

note = "Funding Information: The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason, Cecil Runyons, and Brian Hallahan for technical assistance. This work was supported by the National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation. ",

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AU - Lovell, M. A.

N1 - Funding Information: The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason, Cecil Runyons, and Brian Hallahan for technical assistance. This work was supported by the National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

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N2 - Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.

AB - Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.

KW - Alzheimer's disease

KW - Brain

KW - Four-hydroxynonenal

KW - Lipid peroxidation

KW - Oxidative stress

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IS - 1

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Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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