Four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg

G. R. Buckles, C. Rauskolb, J. L. Villano, F. N. Katz

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The molecular basis of segmentation and regional growth during morphogenesis of Drosophila legs is poorly understood. We show that four-jointed is not only required for these processes, but also can direct ectopic growth and joint initiation when its normal pattern of expression is disturbed. These effects are non-autonomous, consistent with our demonstration of both transmembrane and secreted forms of the protein in vivo. The similarities between four-jointed and Notch phenotypes led us to further investigate the relationships between these pathways. Surprisingly, we find that although four-jointed expression is regulated downstream of Notch activation, four-jointed can induce expression of the Notch ligands, Serrate and Delta, and may thereby participate in a feedback loop with the Notch signaling pathway. We also show that four-jointed interacts with abelson, enabled and dachs, which leads us to suggest that one target of four-jointed signaling is the actin cytoskeleton. Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out.

Original languageEnglish
Pages (from-to)3533-3542
Number of pages10
JournalDevelopment (Cambridge)
Volume128
Issue number18
StatePublished - 2001

Keywords

  • Abelson
  • Dachs
  • Delta
  • Drosophila melanogaster
  • Enabled
  • Four-jointed
  • Leg segmentation
  • Serrate

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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