TY - JOUR
T1 - Four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg
AU - Buckles, G. R.
AU - Rauskolb, C.
AU - Villano, J. L.
AU - Katz, F. N.
PY - 2001
Y1 - 2001
N2 - The molecular basis of segmentation and regional growth during morphogenesis of Drosophila legs is poorly understood. We show that four-jointed is not only required for these processes, but also can direct ectopic growth and joint initiation when its normal pattern of expression is disturbed. These effects are non-autonomous, consistent with our demonstration of both transmembrane and secreted forms of the protein in vivo. The similarities between four-jointed and Notch phenotypes led us to further investigate the relationships between these pathways. Surprisingly, we find that although four-jointed expression is regulated downstream of Notch activation, four-jointed can induce expression of the Notch ligands, Serrate and Delta, and may thereby participate in a feedback loop with the Notch signaling pathway. We also show that four-jointed interacts with abelson, enabled and dachs, which leads us to suggest that one target of four-jointed signaling is the actin cytoskeleton. Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out.
AB - The molecular basis of segmentation and regional growth during morphogenesis of Drosophila legs is poorly understood. We show that four-jointed is not only required for these processes, but also can direct ectopic growth and joint initiation when its normal pattern of expression is disturbed. These effects are non-autonomous, consistent with our demonstration of both transmembrane and secreted forms of the protein in vivo. The similarities between four-jointed and Notch phenotypes led us to further investigate the relationships between these pathways. Surprisingly, we find that although four-jointed expression is regulated downstream of Notch activation, four-jointed can induce expression of the Notch ligands, Serrate and Delta, and may thereby participate in a feedback loop with the Notch signaling pathway. We also show that four-jointed interacts with abelson, enabled and dachs, which leads us to suggest that one target of four-jointed signaling is the actin cytoskeleton. Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out.
KW - Abelson
KW - Dachs
KW - Delta
KW - Drosophila melanogaster
KW - Enabled
KW - Four-jointed
KW - Leg segmentation
KW - Serrate
UR - http://www.scopus.com/inward/record.url?scp=0034796869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034796869&partnerID=8YFLogxK
M3 - Article
C2 - 11566858
AN - SCOPUS:0034796869
SN - 0950-1991
VL - 128
SP - 3533
EP - 3542
JO - Development (Cambridge)
JF - Development (Cambridge)
IS - 18
ER -