TY - JOUR
T1 - Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
AU - Sonnen, Joshua A.
AU - Breitner, John C.
AU - Lovell, Mark A.
AU - Markesbery, William R.
AU - Quinn, Joseph F.
AU - Montine, Thomas J.
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Advances in our understanding of the etiologies and pathogenesis of Alzheimer's disease (AD) highlight a role for free radical-mediated injury to brain regions from early stages of this illness. Here we will review the evidence from transgenic mouse models of AD, autopsy samples, and human biofluids obtained during life paying particular attention to the stage of disease. In addition, we will review the epidemiologic literature that addresses the potential of anti-oxidants to prevent incident dementia from AD, and the clinical trial literature that addresses anti-oxidant preventative or therapeutic strategies for different stage of AD. Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD.
AB - Advances in our understanding of the etiologies and pathogenesis of Alzheimer's disease (AD) highlight a role for free radical-mediated injury to brain regions from early stages of this illness. Here we will review the evidence from transgenic mouse models of AD, autopsy samples, and human biofluids obtained during life paying particular attention to the stage of disease. In addition, we will review the epidemiologic literature that addresses the potential of anti-oxidants to prevent incident dementia from AD, and the clinical trial literature that addresses anti-oxidant preventative or therapeutic strategies for different stage of AD. Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD.
KW - Alzheimer's disease
KW - Anti-oxidants
KW - Mild Cognitive Impairement
KW - Oxidative damage
UR - http://www.scopus.com/inward/record.url?scp=46449119069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46449119069&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2008.04.022
DO - 10.1016/j.freeradbiomed.2008.04.022
M3 - Review article
C2 - 18482592
AN - SCOPUS:46449119069
SN - 0891-5849
VL - 45
SP - 219
EP - 230
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 3
ER -
