Frequency of the SCID gene among Arabian horses in the USA

D. Bernoco, E. Bailey

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring among Arabian horses. The genetic defect responsible for this disease was recently identified as a 5-basepair deletion in the gene encoding DNA-protein kinase catalytic subunit (DNA-PKcs). Horses with one copy of the gene appear normal, while horses with two copies of the gene manifest the disease. The present report describes a PCR-based test for detection of the gene defect and the results from testing 250 randomly selected Arabian horses. The frequency of SCID gene carriers was 8.4% (21/250). Based on the gene frequency reported here, the authors would expect 0.18% (1 out of 567) of Arabian foals to be affected with SCID based on a random breeding population.

Original languageEnglish
Pages (from-to)41-42
Number of pages2
JournalAnimal Genetics
Volume29
Issue number1
DOIs
StatePublished - Feb 1998

Keywords

  • Gene defect
  • Hereditary disease
  • Immunodeficiency
  • SCID

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics

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