From transplanting Schwann cells in experimental rat spinal cord injury to their transplantation into human injured spinal cord in clinical trials

Mary B. Bunge, Paula V. Monje, Aisha Khan, Patrick M. Wood

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

34 Scopus citations

Abstract

Among the potential therapies designed to repair the injured spinal cord is cell transplantation, notably the use of autologous adult human Schwann cells (SCs). Here, we detail some of the critical research accomplished over the last four decades to establish a foundation that enables these cells to be tested in clinical trials. New culture systems allowed novel information to be gained about SCs, including discovering ways to stimulate their proliferation to acquire adequately large numbers for transplantation into the injured human spinal cord. Transplantation of rat SCs into rat models of spinal cord injury has demonstrated that SCs promote repair of injured spinal cord. Additional work required to gain approval from the Food and Drug Administration for the first SC trial in the Miami Project is disclosed. This trial and a second one now underway are described.

Original languageEnglish
Title of host publicationProgress in Brain Research
Pages107-133
Number of pages27
DOIs
StatePublished - 2017

Publication series

NameProgress in Brain Research
Volume231
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

  • Human Schwann cells
  • Schwann cell clinical trials
  • Schwann cell transplantation
  • Spinal cord injury
  • Spinal cord repair

ASJC Scopus subject areas

  • General Neuroscience

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