TY - JOUR
T1 - From white spots to stem cells
T2 - the role of the Kit receptor in mammalian development
AU - Fleischman, Roger A.
PY - 1993/8
Y1 - 1993/8
N2 - The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
AB - The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
UR - http://www.scopus.com/inward/record.url?scp=0027218845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027218845&partnerID=8YFLogxK
U2 - 10.1016/0168-9525(93)90015-A
DO - 10.1016/0168-9525(93)90015-A
M3 - Review article
C2 - 7691001
AN - SCOPUS:0027218845
SN - 0168-9525
VL - 9
SP - 285
EP - 290
JO - Trends in Genetics
JF - Trends in Genetics
IS - 8
ER -