TY - JOUR
T1 - Frontal lobe phosphorus metabolism and neuropsychological function in aging and in alzheimer's disease
AU - Smith, Charles D.
AU - Creed Pettigrew, L.
AU - Avison, Malcolm J.
AU - Kirsch, John E.
AU - Tinkhtman, Alexander J.
AU - Schmitt, Frederick A.
AU - Wermeling, Daniel P.
AU - Wekstein, David R.
AU - Marchkesberry, William R.
PY - 1995/8
Y1 - 1995/8
N2 - 31P Magnetic resonance spectroscopy of the frontal lobe was performed in 17 patients with Alzheimer's disease (AD), 8 elderly controls (EC), and 17 young controls (YC). The phosphocreatine/inorganic phosphate (PCr/Pi) ratio in AD (2.32 ± 0.26 SD) was significantly lower than in EC (2.65 ± 0.41). In AD patients, a correlation was observed between the PCr/Pi ratio and the dementia rating scale (r = −0.50, p = 0.04). A significant positive correlation between PCr/Pi ratio and age was observed in both AD (r = 0.67, p 0.003) and YC (r = 0.63, p 0.006) groups, however, suggesting caution in interpretation of this ratio in AD. We did not find differences between AD, EC, or YC in any other spectroscopic measure. A significant sex difference in the phosphomonoester/phosphodiester ratio (PME/PDE) ratio was observed in AD brain. Females had a lower PME/PDE ratio than males.
AB - 31P Magnetic resonance spectroscopy of the frontal lobe was performed in 17 patients with Alzheimer's disease (AD), 8 elderly controls (EC), and 17 young controls (YC). The phosphocreatine/inorganic phosphate (PCr/Pi) ratio in AD (2.32 ± 0.26 SD) was significantly lower than in EC (2.65 ± 0.41). In AD patients, a correlation was observed between the PCr/Pi ratio and the dementia rating scale (r = −0.50, p = 0.04). A significant positive correlation between PCr/Pi ratio and age was observed in both AD (r = 0.67, p 0.003) and YC (r = 0.63, p 0.006) groups, however, suggesting caution in interpretation of this ratio in AD. We did not find differences between AD, EC, or YC in any other spectroscopic measure. A significant sex difference in the phosphomonoester/phosphodiester ratio (PME/PDE) ratio was observed in AD brain. Females had a lower PME/PDE ratio than males.
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U2 - 10.1002/ana.410380211
DO - 10.1002/ana.410380211
M3 - Article
C2 - 7654066
AN - SCOPUS:0029155604
SN - 0364-5134
VL - 38
SP - 194
EP - 201
JO - Annals of Neurology
JF - Annals of Neurology
IS - 2
ER -