Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Carolyn R. Hofe; Limin Feng; Dominique Zephyr; Arnold J. Stromberg; Bernhard Hennig; Lisa M. Gaetke

doi:10.1016/j.nutres.2014.02.001

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Carolyn R. Hofe
, Limin Feng
, Dominique Zephyr
, Arnold J. Stromberg
, Bernhard Hennig
, Lisa M. Gaetke

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Type 2 diabetes has been shown to occur in response to environmental and genetic influences, among them nutrition; food intake patterns; sedentary lifestyle; body mass index; and exposure to persistent organic pollutants, such as polychlorinated biphenyls (PCBs). Nutrition is essential in the prevention and management of type 2 diabetes and has been shown to modulate the toxicity of PCBs. Serum carotenoid concentrations, considered a reliable biomarker of fruit and vegetable intake, are associated with the reduced probability of chronic diseases, such as type 2 diabetes and cardiovascular disease. Our hypothesis is that fruit and vegetable intake, reflected by serum carotenoid concentrations, is associated with the reduced probability of developing type 2 diabetes in US adults with elevated serum concentrations of PCBs 118, 126, and 153. This cross-sectional study used the Center for Disease Control and Prevention database, National Health and Nutrition Examination Survey 2003-2004, in logistic regression analyses. Overall prevalence of type 2 diabetes was approximately 11.6% depending on the specific PCB. All 3 PCBs were positively associated with the probability of type 2 diabetes. For participants at higher PCB percentiles (eg, 75th and 90th) for PCB 118 and 126, increasing serum carotenoid concentrations were associated with a smaller probability of type 2 diabetes. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.

Original language	English
Pages (from-to)	285-293
Number of pages	9
Journal	Nutrition Research
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.nutres.2014.02.001
State	Published - Apr 2014

Bibliographical note

Funding Information:
The authors would like to thank the volunteers and the research staff of the NHANES 2003-2004. This work was supported by grant P42ES007380 from the National Institutes of Environmental Health Sciences, NIH . National Institutes of Environmental Health Sciences/NIH had no role in the design, analysis, or writing of this article. The authors declare that there are no known conflicts of interest associated with this publication.

Funding

The authors would like to thank the volunteers and the research staff of the NHANES 2003-2004. This work was supported by grant P42ES007380 from the National Institutes of Environmental Health Sciences, NIH . National Institutes of Environmental Health Sciences/NIH had no role in the design, analysis, or writing of this article. The authors declare that there are no known conflicts of interest associated with this publication.

Funders	Funder number
National Institutes of Health/National Institute of Environmental Health Sciences
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)	P42ES007380

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Environmental health
NHANES, type 2 diabetes
Nutrition
Polychlorinated biphenyls, PCBs
Serum carotenoids

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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Hofe, C. R., Feng, L., Zephyr, D., Stromberg, A. J., Hennig, B., & Gaetke, L. M. (2014). Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004. Nutrition Research, 34(4), 285-293. https://doi.org/10.1016/j.nutres.2014.02.001

@article{178001f054fb40f884a458194ff583c1,

title = "Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004",

abstract = "Type 2 diabetes has been shown to occur in response to environmental and genetic influences, among them nutrition; food intake patterns; sedentary lifestyle; body mass index; and exposure to persistent organic pollutants, such as polychlorinated biphenyls (PCBs). Nutrition is essential in the prevention and management of type 2 diabetes and has been shown to modulate the toxicity of PCBs. Serum carotenoid concentrations, considered a reliable biomarker of fruit and vegetable intake, are associated with the reduced probability of chronic diseases, such as type 2 diabetes and cardiovascular disease. Our hypothesis is that fruit and vegetable intake, reflected by serum carotenoid concentrations, is associated with the reduced probability of developing type 2 diabetes in US adults with elevated serum concentrations of PCBs 118, 126, and 153. This cross-sectional study used the Center for Disease Control and Prevention database, National Health and Nutrition Examination Survey 2003-2004, in logistic regression analyses. Overall prevalence of type 2 diabetes was approximately 11.6\% depending on the specific PCB. All 3 PCBs were positively associated with the probability of type 2 diabetes. For participants at higher PCB percentiles (eg, 75th and 90th) for PCB 118 and 126, increasing serum carotenoid concentrations were associated with a smaller probability of type 2 diabetes. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.",

keywords = "Environmental health, NHANES, type 2 diabetes, Nutrition, Polychlorinated biphenyls, PCBs, Serum carotenoids",

author = "Hofe, \{Carolyn R.\} and Limin Feng and Dominique Zephyr and Stromberg, \{Arnold J.\} and Bernhard Hennig and Gaetke, \{Lisa M.\}",

note = "Funding Information: The authors would like to thank the volunteers and the research staff of the NHANES 2003-2004. This work was supported by grant P42ES007380 from the National Institutes of Environmental Health Sciences, NIH . National Institutes of Environmental Health Sciences/NIH had no role in the design, analysis, or writing of this article. The authors declare that there are no known conflicts of interest associated with this publication. ",

year = "2014",

month = apr,

doi = "10.1016/j.nutres.2014.02.001",

language = "English",

volume = "34",

pages = "285--293",

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}

Hofe, CR, Feng, L, Zephyr, D, Stromberg, AJ, Hennig, B & Gaetke, LM 2014, 'Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004', Nutrition Research, vol. 34, no. 4, pp. 285-293. https://doi.org/10.1016/j.nutres.2014.02.001

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004. / Hofe, Carolyn R.; Feng, Limin; Zephyr, Dominique et al.
In: Nutrition Research, Vol. 34, No. 4, 04.2014, p. 285-293.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes

T2 - National Health and Nutrition Examination Survey 2003-2004

AU - Hofe, Carolyn R.

AU - Feng, Limin

AU - Zephyr, Dominique

AU - Stromberg, Arnold J.

AU - Hennig, Bernhard

AU - Gaetke, Lisa M.

N1 - Funding Information: The authors would like to thank the volunteers and the research staff of the NHANES 2003-2004. This work was supported by grant P42ES007380 from the National Institutes of Environmental Health Sciences, NIH . National Institutes of Environmental Health Sciences/NIH had no role in the design, analysis, or writing of this article. The authors declare that there are no known conflicts of interest associated with this publication.

PY - 2014/4

Y1 - 2014/4

N2 - Type 2 diabetes has been shown to occur in response to environmental and genetic influences, among them nutrition; food intake patterns; sedentary lifestyle; body mass index; and exposure to persistent organic pollutants, such as polychlorinated biphenyls (PCBs). Nutrition is essential in the prevention and management of type 2 diabetes and has been shown to modulate the toxicity of PCBs. Serum carotenoid concentrations, considered a reliable biomarker of fruit and vegetable intake, are associated with the reduced probability of chronic diseases, such as type 2 diabetes and cardiovascular disease. Our hypothesis is that fruit and vegetable intake, reflected by serum carotenoid concentrations, is associated with the reduced probability of developing type 2 diabetes in US adults with elevated serum concentrations of PCBs 118, 126, and 153. This cross-sectional study used the Center for Disease Control and Prevention database, National Health and Nutrition Examination Survey 2003-2004, in logistic regression analyses. Overall prevalence of type 2 diabetes was approximately 11.6% depending on the specific PCB. All 3 PCBs were positively associated with the probability of type 2 diabetes. For participants at higher PCB percentiles (eg, 75th and 90th) for PCB 118 and 126, increasing serum carotenoid concentrations were associated with a smaller probability of type 2 diabetes. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.

AB - Type 2 diabetes has been shown to occur in response to environmental and genetic influences, among them nutrition; food intake patterns; sedentary lifestyle; body mass index; and exposure to persistent organic pollutants, such as polychlorinated biphenyls (PCBs). Nutrition is essential in the prevention and management of type 2 diabetes and has been shown to modulate the toxicity of PCBs. Serum carotenoid concentrations, considered a reliable biomarker of fruit and vegetable intake, are associated with the reduced probability of chronic diseases, such as type 2 diabetes and cardiovascular disease. Our hypothesis is that fruit and vegetable intake, reflected by serum carotenoid concentrations, is associated with the reduced probability of developing type 2 diabetes in US adults with elevated serum concentrations of PCBs 118, 126, and 153. This cross-sectional study used the Center for Disease Control and Prevention database, National Health and Nutrition Examination Survey 2003-2004, in logistic regression analyses. Overall prevalence of type 2 diabetes was approximately 11.6% depending on the specific PCB. All 3 PCBs were positively associated with the probability of type 2 diabetes. For participants at higher PCB percentiles (eg, 75th and 90th) for PCB 118 and 126, increasing serum carotenoid concentrations were associated with a smaller probability of type 2 diabetes. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.

KW - Environmental health

KW - NHANES, type 2 diabetes

KW - Nutrition

KW - Polychlorinated biphenyls, PCBs

KW - Serum carotenoids

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UR - https://www.scopus.com/pages/publications/84899633628#tab=citedBy

U2 - 10.1016/j.nutres.2014.02.001

DO - 10.1016/j.nutres.2014.02.001

M3 - Article

C2 - 24774064

AN - SCOPUS:84899633628

SN - 0271-5317

VL - 34

SP - 285

EP - 293

JO - Nutrition Research

JF - Nutrition Research

IS - 4

ER -

Hofe CR, Feng L, Zephyr D, Stromberg AJ, Hennig B, Gaetke LM. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004. Nutrition Research. 2014 Apr;34(4):285-293. doi: 10.1016/j.nutres.2014.02.001

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Fingerprint

Cite this