Fulminant Wilson's disease managed with plasmapheresis as a bridge to liver transplant

Talal Hilal, R. Scott Morehead

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


New-onset jaundice can be a manifestation of multiple pathologic processes including hemolysis, parenchymal liver disease, and cholestasis; the differential diagnosis is broad and requires a systematic approach. We report a case of a patient who presented with jaundice after starting minocycline for the treatment of acne vulgaris and rapidly developed fulminant liver failure found to be due to Wilson's disease. She also manifested severe Coomb's negative hemolytic anemia and renal failure secondary to hepatorenal syndrome. As a bridge to liver transplant, she was successfully treated with plasmapheresis to decrease serum copper in addition to hemodialysis for acidosis and hyperkalemia. She was able to receive a liver and made a full recovery. The case highlights the use of plasmapheresis as an adjunctive treatment modality in cases of fulminant liver failure due to Wilson's disease.

Original languageEnglish
Article number672985
JournalCase Reports in Medicine
StatePublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 Talal Hilal and R. Scott Morehead.

ASJC Scopus subject areas

  • General Medicine


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