Function of alternative splicing

O. Kelemen, P. Convertini, Z. Zhang, Y. Wen, M. Shen, M. Falaleeva, S. Stamm

Research output: Contribution to journalArticlepeer-review


Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects. Experimental analysis of these protein isoforms showed that alternative splicing regulates binding between proteins, between proteins and nucleic acids as well as between proteins and membranes. Alternative splicing regulates the localization of proteins, their enzymatic properties and their interaction with ligands. In most cases, changes caused by individual splicing isoforms are small. However, cells typically coordinate numerous changes in 'splicing programs', which can have strong effects on cell proliferation, cell survival and properties of the nervous system. Due to its widespread usage and molecular versatility, alternative splicing emerges as a central element in gene regulation that interferes with almost every biological function analyzed.
Original languageAmerican English
Pages (from-to)1-30
Number of pages30
Issue number1
StatePublished - 2013

Bibliographical note

Kelemen, Olga Convertini, Paolo Zhang, Zhaiyi Wen, Yuan Shen, Manli Falaleeva, Marina Stamm, Stefan eng R01 GM083187/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Netherlands Gene. 2013 Feb 1;514(1):1-30. doi: 10.1016/j.gene.2012.07.083. Epub 2012 Aug 15.


  • *Alternative Splicing Animals Evolution, Molecular Exons Gene Expression Humans Models, Genetic Protein Isoforms/genetics/metabolism RNA, Messenger/genetics/metabolism Transcription Factors/metabolism


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