Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine

Fang Li, Jianting Shi, Hong S. Lu, Hanrui Zhang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Novel genetic loci associated with cardiovascular diseases will continue to emerge through GWAS in diverse populations. The post-GWAS functional studies will dedicate to delineating the causal genetic variants and genes and the underlying biological mechanisms. Novel functional genomic technologies at single-cell and single-molecule level will further reveal cell type- specific regulatory mechanisms.56The promise of functional genomics is to understand the function of all components of the genome, and ultimately translate genetic findings toward clinical applications in the diagnosis and treatment of both rare and common cardiovascular diseases.

Original languageEnglish
Pages (from-to)E188-E194
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume39
Issue number9
DOIs
StatePublished - Sep 1 2019

Bibliographical note

Funding Information:
The authors’ research work has received funding from the National Center for Advancing Translational Sciences (NCATS) and National Institutes of Health (NIH) through grant number UL1TR001873, the NIH R00HL130574 (to H. Zhang), and R01HL139748 (to H.S. Lu). The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NCATS and the NIH.

Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • cardiovascular diseases
  • gene expression
  • genomics
  • humans
  • phenotype

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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