Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine

Fang Li; Jianting Shi; Hong S. Lu; Hanrui Zhang

doi:10.1161/ATVBAHA.119.312579

Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine

Fang Li, Jianting Shi, Hong S. Lu, Hanrui Zhang

Physiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Novel genetic loci associated with cardiovascular diseases will continue to emerge through GWAS in diverse populations. The post-GWAS functional studies will dedicate to delineating the causal genetic variants and genes and the underlying biological mechanisms. Novel functional genomic technologies at single-cell and single-molecule level will further reveal cell type- specific regulatory mechanisms.⁵⁶The promise of functional genomics is to understand the function of all components of the genome, and ultimately translate genetic findings toward clinical applications in the diagnosis and treatment of both rare and common cardiovascular diseases.

Original language	English
Pages (from-to)	E188-E194
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	39
Issue number	9
DOIs	https://doi.org/10.1161/ATVBAHA.119.312579
State	Published - Sep 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.

Keywords

cardiovascular diseases
gene expression
genomics
humans
phenotype

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/ATVBAHA.119.312579

Cite this

@article{44782ff2e0af497a95dfdb777e5338e6,

title = "Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine",

abstract = "Novel genetic loci associated with cardiovascular diseases will continue to emerge through GWAS in diverse populations. The post-GWAS functional studies will dedicate to delineating the causal genetic variants and genes and the underlying biological mechanisms. Novel functional genomic technologies at single-cell and single-molecule level will further reveal cell type- specific regulatory mechanisms.56The promise of functional genomics is to understand the function of all components of the genome, and ultimately translate genetic findings toward clinical applications in the diagnosis and treatment of both rare and common cardiovascular diseases.",

keywords = "cardiovascular diseases, gene expression, genomics, humans, phenotype",

author = "Fang Li and Jianting Shi and Lu, {Hong S.} and Hanrui Zhang",

year = "2019",

month = sep,

day = "1",

doi = "10.1161/ATVBAHA.119.312579",

language = "English",

volume = "39",

pages = "E188--E194",

number = "9",

}

TY - JOUR

T1 - Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine

AU - Li, Fang

AU - Shi, Jianting

AU - Lu, Hong S.

AU - Zhang, Hanrui

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Novel genetic loci associated with cardiovascular diseases will continue to emerge through GWAS in diverse populations. The post-GWAS functional studies will dedicate to delineating the causal genetic variants and genes and the underlying biological mechanisms. Novel functional genomic technologies at single-cell and single-molecule level will further reveal cell type- specific regulatory mechanisms.56The promise of functional genomics is to understand the function of all components of the genome, and ultimately translate genetic findings toward clinical applications in the diagnosis and treatment of both rare and common cardiovascular diseases.

AB - Novel genetic loci associated with cardiovascular diseases will continue to emerge through GWAS in diverse populations. The post-GWAS functional studies will dedicate to delineating the causal genetic variants and genes and the underlying biological mechanisms. Novel functional genomic technologies at single-cell and single-molecule level will further reveal cell type- specific regulatory mechanisms.56The promise of functional genomics is to understand the function of all components of the genome, and ultimately translate genetic findings toward clinical applications in the diagnosis and treatment of both rare and common cardiovascular diseases.

KW - cardiovascular diseases

KW - gene expression

KW - genomics

KW - humans

KW - phenotype

UR - http://www.scopus.com/inward/record.url?scp=85071548065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071548065&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.119.312579

DO - 10.1161/ATVBAHA.119.312579

M3 - Article

C2 - 31433696

AN - SCOPUS:85071548065

SN - 1079-5642

VL - 39

SP - E188-E194

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 9

ER -

Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this