TY - JOUR
T1 - Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis
AU - Yeo, Yun Soo
AU - Nybo, S. Eric
AU - Chittiboyina, Amar G.
AU - Weerasooriya, Aruna D.
AU - Wang, Yan Hong
AU - Góngora-Castillo, Elsa
AU - Vaillancourt, Brieanne
AU - Buell, C. Robin
AU - Dellapenna, Dean
AU - Celiz, Mary Dawn
AU - Daniel Jones, A.
AU - Wurtele, Eve Syrkin
AU - Ransom, Nick
AU - Dudareva, Natalia
AU - Shaaban, Khaled A.
AU - Tibrewal, Nidhi
AU - Chandra, Suman
AU - Smillie, Troy
AU - Khan, Ikhlas A.
AU - Coates, Robert M.
AU - Watt, David S.
AU - Chappell, Joe
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Background: Therapeutic values of Valeriana officinalis have been associated with sesquiterpenes whose biosynthetic origins have remained enigmatic. Results: A cyclobutenyl intermediate in the catalytic cascade of valerena-1,10-diene synthase is reported. Conclusion: A new class of sesquiterpene synthases for the biosynthesis of sesquiterpenes harboring isobutenyl functional groups is proposed. Significance: Similar catalytic mechanisms from evolutionarily diverse organisms are proposed and portend sources for sesquiterpene diversity.
AB - Background: Therapeutic values of Valeriana officinalis have been associated with sesquiterpenes whose biosynthetic origins have remained enigmatic. Results: A cyclobutenyl intermediate in the catalytic cascade of valerena-1,10-diene synthase is reported. Conclusion: A new class of sesquiterpene synthases for the biosynthesis of sesquiterpenes harboring isobutenyl functional groups is proposed. Significance: Similar catalytic mechanisms from evolutionarily diverse organisms are proposed and portend sources for sesquiterpene diversity.
UR - https://www.scopus.com/pages/publications/84873322358
UR - https://www.scopus.com/pages/publications/84873322358#tab=citedBy
U2 - 10.1074/jbc.M112.415836
DO - 10.1074/jbc.M112.415836
M3 - Article
C2 - 23243312
AN - SCOPUS:84873322358
SN - 0021-9258
VL - 288
SP - 3163
EP - 3173
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 5
ER -