Functional Magnetic Resonance Imaging

A. L. Lin, H. Y. Monica Way

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Magnetic resonance imaging (MRI) is the most important imaging advance since Conrad Röntgen introduced x-rays in 1895. Although researchers have long appreciated the unparalleled importance of MRI in diagnostic medicine, the emergence in the early 1990s of functional MRI (fMRI) - which measures hemodynamic changes after enhanced neural activity - had a real impact on basic cognitive neuroscience research. fMRI was developed on the basis of a series of phenomena discovered beginning in the late nineteenth century, including the tight coupLing between neuronal activity and brain-blood flow, the distinct magnetic property between oxygenated and deoxygenated hemoglobin, and the flow-metaboLism uncoupLing under neuronal activation. This article reviews the historical events that led to the discovery of fMRI, basic principles of fMRI mapping, and appLications. We also discuss Limitations of fMRI, including the pitfall of interpreting data and future directions.

Original languageEnglish
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
Number of pages14
ISBN (Electronic)9780123864567
StatePublished - Jan 1 2014


  • ANLS
  • BOlD
  • CaLibrated fMRI
  • CBF
  • CMR
  • CMRO
  • FMRI
  • PET
  • Resting-state functional connectivity

ASJC Scopus subject areas

  • Medicine (all)


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