Fundamental reaction pathway and free energy profile for inhibition of proteasome by epoxomicin

Chemistry

• % Inhibition 100%
• Atom 16%
• Carbon 33%
• Chemical Reaction 100%
• Chemical Reaction Product 16%
• Dioxygen 16%
• Energy Barrier 33%
• Epoxide 33%
• First Principle 16%
• Gibbs Free Energy 100%
• Group 16%
• Inhibitor 16%
• Kinetics Type 16%
• Molecules 16%
• Nucleophilic Substitution 16%
• Peptide 33%
• Procedure 16%
• Proteasome Inhibitor 16%
• Protein 16%
• Proton Transfer 50%
• Rate-Determining Step 16%
• Reaction Mechanism 33%
• Reaction Step 16%
• Ring Opening Reaction 16%
• Transfer Process 16%
• Water Type 33%

Biochemistry, Genetics and Molecular Biology

• Atom 20%
• Comprehension 20%
• Energy 100%
• Kinetics 20%
• Molecule 20%
• Morpholino 40%
• Nucleophilicity 40%
• Peptide 40%
• Perception 20%
• Proteasome 100%
• Proteasome Inhibitor 20%
• Protein 20%
• Proton Transport 60%
• Ring Opening 20%

Chemical Engineering

• Carbon 40%
• Gibbs Free Energy 100%
• Oxygen 20%
• Water 40%