Furanone derivatives from terrestrial Streptomyces spp.

Muhammad Arfan, Khaled A. Shaaban, Anja Schuf̈fler, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Chemical investigation of the terrestrial Streptomyces sp. isolates GT2005/020 and ANK148 led to the isolation of two microbial furanone derivatives, 5-hydroxy-4-methylnaphtho[1,2-b]furan-3-one (1) and 4-hydroxy-5-methyl-furan-3-one (2), respectively, which have some similarity to quorum sensing molecules of the AI-2 type. In addition, the known compounds chalcomycin, ferulic acid, indole-3-acetic acid, uracil, thymine, 2′-deoxy-thymidin, monensin B (3), phencomycin, and 1-acetyl-β- carboline were isolated. The structures of 1 and 2 were deduced from extensive studies of NMR (1D and 2D) and mass spectra. Additionally, the complete NMR shift assignments for monensin B (3) using H-H COSY, HMQC and HMBC experiments are reported here for the first time. We are describing the taxonomy and fermentation of the producing strains, the structure elucidation of the new metabolites and their bioactivity. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)1199-1202
Number of pages4
JournalNatural Product Communications
Issue number9
StatePublished - Sep 2012


  • Furanones
  • Monensin
  • Streptomyces sp

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine


Dive into the research topics of 'Furanone derivatives from terrestrial Streptomyces spp.'. Together they form a unique fingerprint.

Cite this