Furanosesquiterpenoids of Commiphora myrrha

N. Zhu, H. Kikuzaki, S. Sheng, S. Sang, M. M. Rafi, M. Wang, N. Nakatani, R. S. DiPaola, R. T. Rosen, C. T. Ho

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56 Scopus citations


An investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one(3),rel-2R-methoxy-4R- furanogermacr-1(10)E-en-6-one(4),furanogermacra-1(10)Z,4Z-dien-6-one, 1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5β-isopropenyl-3,6β-dimethyl-6-vinylbenzofuran- 4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay.

Original languageEnglish
Pages (from-to)1460-1462
Number of pages3
JournalJournal of Natural Products
Issue number11
StatePublished - 2001

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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