30 Scopus citations


Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways. The fusion of satellite cells, driven by cell-autonomous and/or extrinsic factors, contributes new myonuclei to muscle fibers, associates with load-induced hypertrophy, and may support focal membrane damage repair and long-term myonuclear transcriptional output. Recent studies have also revealed that satellite cells communicate within their niche to mediate muscle remodeling in response to resistance exercise, regulating the activity of numerous cell types through various mechanisms such as secretory signaling and cell–cell contact. Muscular adaptation to resistance and endurance activity can be initiated and sustained for a period of time in the absence of satellite cells, but satellite cell participation is ultimately required to achieve full adaptive potential, be it growth, function, or proprioceptive coordination. While significant progress has been made in understanding the roles of satellite cells in adult muscle over the last few decades, many conclusions have been extrapolated from regeneration studies. This review highlights our current understanding of satellite cell behavior and contributions to adaptation outside of regeneration in adult muscle, as well as the roles of satellite cells beyond fusion and myonuclear accretion, which are gaining broader recognition.

Original languageEnglish
Article numbere21893
JournalFASEB Journal
Issue number10
StatePublished - Oct 2021

Bibliographical note

Funding Information:
This work was supported by NIH grants from the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (AR060701 to CAP and JJM, AR071753 to KAM) and National Institute on Aging (AG049086 to CAP and JJM and AG063994 to KAM). Figure 1 was generated using BioRender.

Publisher Copyright:
© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology


  • endurance exercise
  • extracellular vesicles
  • hypertrophy
  • muscle stem cells
  • myonuclei
  • regeneration
  • resistance exercise

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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