Personalized prescription and pharmacogenomics are related concepts, but are not the same. The 'Introduction' describes the concept of pharmacogenomics, which can be included within personalized prescription, and the role of the Human Genome Project and the Food and Drug Administration in promoting advances in these concepts. In the author's comprehensive view of personalized prescription, clinicians need to consider genetic, environmental and personal variables when prescribing any medication. Known important genetic variables in specific drug responses can be explored by pharmacogenetic tests. Environmental variables - such as co-medication, herb supplements, foods, beverages and smoking - may be much more important than genetic factors for some drugs. Personal factors such as age, gender or medical illnesses (renal or hepatic insufficiency) may be crucial personal variables in the response to some other drugs. The pharmacological knowledge needed to understand personalized prescription includes pharmacokinetics and pharmacodynamic actions, efficacy and safety, idiosyncratic and dose-related adverse drug reactions, prescriber's role and therapeutic window, and linear versus non-linear pharmacokinetics. The applications of these pharmacological concepts in psychiatry are briefly reviewed. Risperidone personalized prescription is provided as an example by describing personalized risperidone selection and personalized risperidone dosing. The future of pharmacogenomic tests and personalized prescription in psychiatry is briefly summarized.
|Title of host publication||Advances in Biological Psychiatry|
|Editors||Matthias Schwab, Matthias Schwab, Kaschka Wolfgang, Edoardo Spina|
|Number of pages||17|
|State||Published - 2010|
|Name||Advances in Biological Psychiatry|
Bibliographical noteFunding Information:
ACKNOWLEDGMENT Data collection and sharing of this project were funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 BG024904) and DOD ADNI (Department of Defense Bward no. W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering and through generous contributions from the
© 2010 by S. Karger AG. All rights reserved.
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry