GAPDH in neuroblastoma: Functions in metabolism and survival

Kevin Cornett, Anna Puderbaugh, Olivia Back, Rolf Craven

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in nerve cells around the adrenal gland, although other locations are possible. Neuroblastomas rely on glycolysis as a source of energy and metabolites, and the enzymes that catalyze glycolysis are potential therapeutic targets for neuroblastoma. Furthermore, glycolysis provides a protective function against DNA damage, and there is evidence that glycolysis inhibitors may improve outcomes from other cancer treatments. This mini-review will focus on glyceraldehyde 3-phosphate dehydrogenase (GAPDH), one of the central enzymes in glycolysis. GAPDH has a key role in metabolism, catalyzing the sixth step in glycolysis and generating NADH. GAPDH also has a surprisingly diverse number of localizations, including the nucleus, where it performs multiple functions, and the plasma membrane. One membrane-associated function of GAPDH is stimulating glucose uptake, consistent with a role for GAPDH in energy and metabolite production. The plasma membrane localization of GAPDH and its role in glucose uptake have been verified in neuroblastoma. Membrane-associated GAPDH also participates in iron uptake, although this has not been tested in neuroblastoma. Finally, GAPDH activates autophagy through a nuclear complex with Sirtuin. This review will discuss these activities and their potential role in cancer metabolism, treatment and drug resistance.

Original languageEnglish
Article number979683
JournalFrontiers in Oncology
Volume12
DOIs
StatePublished - Oct 4 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Cornett, Puderbaugh, Back and Craven.

Keywords

  • autophagy
  • glucose
  • glycolysis
  • metabolism
  • neuroblastoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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