GAPDH in neuroblastoma: Functions in metabolism and survival

Kevin Cornett, Anna Puderbaugh, Olivia Back, Rolf Craven

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in nerve cells around the adrenal gland, although other locations are possible. Neuroblastomas rely on glycolysis as a source of energy and metabolites, and the enzymes that catalyze glycolysis are potential therapeutic targets for neuroblastoma. Furthermore, glycolysis provides a protective function against DNA damage, and there is evidence that glycolysis inhibitors may improve outcomes from other cancer treatments. This mini-review will focus on glyceraldehyde 3-phosphate dehydrogenase (GAPDH), one of the central enzymes in glycolysis. GAPDH has a key role in metabolism, catalyzing the sixth step in glycolysis and generating NADH. GAPDH also has a surprisingly diverse number of localizations, including the nucleus, where it performs multiple functions, and the plasma membrane. One membrane-associated function of GAPDH is stimulating glucose uptake, consistent with a role for GAPDH in energy and metabolite production. The plasma membrane localization of GAPDH and its role in glucose uptake have been verified in neuroblastoma. Membrane-associated GAPDH also participates in iron uptake, although this has not been tested in neuroblastoma. Finally, GAPDH activates autophagy through a nuclear complex with Sirtuin. This review will discuss these activities and their potential role in cancer metabolism, treatment and drug resistance.

Original languageEnglish
Article number979683
JournalFrontiers in Oncology
StatePublished - Oct 4 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Cornett, Puderbaugh, Back and Craven.


  • autophagy
  • glucose
  • glycolysis
  • metabolism
  • neuroblastoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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