Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration

T. J. Gana, B. R. MacPherson, J. Koo

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


To determine whether topical misoprostol (a synthetic PGE1 analog) pretreatment will increase or prevent a decrease in gastric mucosal blood flow (GMBF) during topical aspirin administration, we studied focal GMBF simultaneously by hydrogen gas clearance in a split canine gastric chamber model with one side as control. In the test chamber, immediately after topical misoprostol, there was a transient and significant increase (18%) in GMBF (55.71 ± 7.80 to 65.84 ± 6.12 mL/min/100 g; p < 0.05). After 15 minutes, GMBF returned to premisoprostol levels and then showed a graded drop throughout the aspirin and postaspirin periods. No grossly visible mucosal lesions were observed. In the control chamber, mucosal lesions were observed 45 minutes after aspirin administration accompanied by a graded drop in GMBF throughout the experiments. Misoprostol neither produced a sustained increase in GMBF nor prevented the subsequent reduction in GMBF induced by aspirin. Therefore, maintenance of GMBF may not be important in cytoprotection by misoprostol. The sustained nonparietal secretion induced by this synthetic PGE1 analog may be important in gastric cytoprotection.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalAnnals of Surgery
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration'. Together they form a unique fingerprint.

Cite this