TY - JOUR
T1 - Gastrointestinal growth factors and neoplasia
AU - Evers, B. Mark
PY - 2005/8
Y1 - 2005/8
N2 - Gastrointestinal (GI) hormones are chemical messengers that have been recognized for over a century as regulatory factors for normal physiologic functions in the GI tract and pancreas, including absorption, secretion, motility, and digestion. These hormones traditionally act in a true endocrine fashion with release from a distant site to regulate physiologic functions of specific target organs. In general, GI hormones bind to their G-protein-coupled receptors (GPCRs) to produce their endocrine effects. In addition to effects on physiologic functions of the GI tract and pancreas, selected GI hormones can act in an endocrine, paracrine, and/or autocrine fashion to stimulate the proliferation of normal and neoplastic GI tissues as well as non-GI tissues. This review will focus on effects of GI hormones on neoplastic tissues concentrating on the hormones that have been best characterized for these effects.
AB - Gastrointestinal (GI) hormones are chemical messengers that have been recognized for over a century as regulatory factors for normal physiologic functions in the GI tract and pancreas, including absorption, secretion, motility, and digestion. These hormones traditionally act in a true endocrine fashion with release from a distant site to regulate physiologic functions of specific target organs. In general, GI hormones bind to their G-protein-coupled receptors (GPCRs) to produce their endocrine effects. In addition to effects on physiologic functions of the GI tract and pancreas, selected GI hormones can act in an endocrine, paracrine, and/or autocrine fashion to stimulate the proliferation of normal and neoplastic GI tissues as well as non-GI tissues. This review will focus on effects of GI hormones on neoplastic tissues concentrating on the hormones that have been best characterized for these effects.
KW - Bombesin
KW - CCK
KW - GI hormones
KW - Gastrin
KW - Neoplasias
KW - Neurotensin
UR - http://www.scopus.com/inward/record.url?scp=22044431629&partnerID=8YFLogxK
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U2 - 10.1016/j.amjsurg.2005.05.027
DO - 10.1016/j.amjsurg.2005.05.027
M3 - Article
C2 - 16023446
AN - SCOPUS:22044431629
SN - 0002-9610
VL - 190
SP - 279
EP - 284
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 2
ER -