Gauging Working Memory Capacity From Differential Resting Brain Oscillations in Older Individuals With A Wearable Device

Soheil Borhani, Xiaopeng Zhao, Margaret R. Kelly, Karah E. Gottschalk, Fengpei Yuan, Gregory A. Jicha, Yang Jiang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Working memory is a core cognitive function and its deficits is one of the most common cognitive impairments. Reduced working memory capacity manifests as reduced accuracy in memory recall and prolonged speed of memory retrieval in older adults. Currently, the relationship between healthy older individuals’ age-related changes in resting brain oscillations and their working memory capacity is not clear. Eyes-closed resting electroencephalogram (rEEG) is gaining momentum as a potential neuromarker of mild cognitive impairments. Wearable and wireless EEG headset measuring key electrophysiological brain signals during rest and a working memory task was utilized. This research’s central hypothesis is that rEEG (e.g., eyes closed for 90 s) frequency and network features are surrogate markers for working memory capacity in healthy older adults. Forty-three older adults’ memory performance (accuracy and reaction times), brain oscillations during rest, and inter-channel magnitude-squared coherence during rest were analyzed. We report that individuals with a lower memory retrieval accuracy showed significantly increased alpha and beta oscillations over the right parietal site. Yet, faster working memory retrieval was significantly correlated with increased delta and theta band powers over the left parietal sites. In addition, significantly increased coherence between the left parietal site and the right frontal area is correlated with the faster speed in memory retrieval. The frontal and parietal dynamics of resting EEG is associated with the “accuracy and speed trade-off” during working memory in healthy older adults. Our results suggest that rEEG brain oscillations at local and distant neural circuits are surrogates of working memory retrieval’s accuracy and processing speed. Our current findings further indicate that rEEG frequency and coherence features recorded by wearable headsets and a brief resting and task protocol are potential biomarkers for working memory capacity. Additionally, wearable headsets are useful for fast screening of cognitive impairment risk.

Original languageEnglish
Article number625006
JournalFrontiers in Aging Neuroscience
Volume13
DOIs
StatePublished - Feb 19 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health/ National Institute on Aging (NIH/NIA) (grant numbers 1R56 AG 060608, P30 AG028383); Alzheimer’s Tennessee.

Publisher Copyright:
© Copyright © 2021 Borhani, Zhao, Kelly, Gottschalk, Yuan, Jicha and Jiang.

Keywords

  • EEG
  • coherence analysis
  • mild cognitive impairment
  • resting-state
  • working memory

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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