TY - JOUR
T1 - GAW20
T2 - Methods and strategies for the new frontiers of epigenetics and pharmacogenomics
AU - Tintle, Nathan L.
AU - Fardo, David W.
AU - De Andrade, Mariza
AU - Aslibekyan, Stella
AU - Bailey, Julia N.
AU - Bermejo, Justo Lorenzo
AU - Cantor, Rita M.
AU - Ghosh, Saurabh
AU - Melton, Philip
AU - Wang, Xuexia
AU - MacCluer, Jean W.
AU - Almasy, Laura
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/9/17
Y1 - 2018/9/17
N2 - GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual research groups were extensively discussed prior, during, and after the Workshop in groups based on discussion themes, before being submitted for publication.
AB - GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual research groups were extensively discussed prior, during, and after the Workshop in groups based on discussion themes, before being submitted for publication.
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U2 - 10.1186/s12919-018-0113-1
DO - 10.1186/s12919-018-0113-1
M3 - Article
AN - SCOPUS:85053452720
SN - 1753-6561
VL - 12
JO - BMC Proceedings
JF - BMC Proceedings
M1 - 26
ER -