Abstract
GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual research groups were extensively discussed prior, during, and after the Workshop in groups based on discussion themes, before being submitted for publication.
| Original language | English |
|---|---|
| Article number | 26 |
| Journal | BMC Proceedings |
| Volume | 12 |
| DOIs | |
| State | Published - Sep 17 2018 |
Bibliographical note
Publisher Copyright:© 2018 The Author(s).
Funding
Publication of this article was supported by NIH R01 GM031575. We are grateful to the GOLDN study for allowing GAW20 participants to use the data set around which this Workshop was based. The GOLDN study is funded by National Institutes of Health (NIH) R01 HL091357 (Arnett), NIH R01 HL104135 (Arnett), and NIH K01 HL136700 (Aslibekyan). Publication charges are paid by NIH R01 GM031575. The GAW is supported by NIH grant R01 GM031575. The GAW20 discussion groups were led by Mariza de Andrade, Stella Aslibekyan, Julia Bailey, Justo Lorenzo Bermejo, Rita Cantor, Saurabh Ghosh, Philip Melton, Nathan Tintle, and Xuexia Wang. We are grateful to them for their work before, during, and after GAW20 in initiating, organizing, and overseeing pre-Workshop communication, group discussions, group presentations, and summary paper writing. A total of 46 individuals assisted in peer review of the papers in this volume: Christopher Amos, Elizabeth Atkinson, Joan Bailey-Wilson, Sheila Barton, Elizabeth Blue, Anne-Laure Boulesteix, Shelley Bull, Gemma Cadby, Jenny Chang-Claude, Brandon Coombes, Heather Cordell, Robert Culverhouse, Adrienne Cupples, David Fardo, Christine Fischer, Nora Francheschini, Derek Gordon, Han Hao, Audrey Hendricks, Johannes Heise, Yijuan Hu, Anne Justice, Inke König, Johannes Martini, Kari North, Michael Nothnagel, Sara Pendergrass, Elizabeth Pugh, Steve Rich, Stephanie Santorico, André Scherag, Mary Sehl, Noha Sharafeldin, Kim Siegmund, Henner Simianer, Claire Simpson, Janet Sinsheimer, Eric Sobel, Hans Stassen, March Suchard, Jae-Hoon Sul, Maggie Haitian Wang, Ellen Wijsman, Zheng Xu, Peng Zhang, Mark Kos, and Zhaogong Zhang. We are grateful to them for their constructive comments, criticisms, and feedback. Beginning with GAW7 in 1991, Vanessa Olmo has been responsible for major aspects of Workshop organization. We are grateful to her for the many things she does that keep GAW running smoothly, which includes interacting with participants, organizers, editors, and publishers; coordinating data requests and data distribution; facilitating selection of Workshop sites and making local arrangements; maintaining the GAW web site and mailing list; and preparing many aspects of the GAW proceedings. Stella Aslibekyan, Michael Province, Devin Absher, and Donna Arnett participated in data set preparation. Aldi Kraja, Ping An, and Petra Lenzini worked on data simulation. Zenaida Mendoza created the graphics and layout of the pre-Workshop volume. Thomas Dyer and Mark Kos assisted with data distribution efforts. Hannah Lazarus assisted with pre-workshop organization and onsite meeting management. Sophie Colunga liaised with authors and managed the publication process. Malinda Mann typeset the articles for these proceedings. The GAW Advisory Committee assists with planning for the GAWs, including selection of workshop sites and topics. At the time of GAW20, its members were: Laura Almasy (chair), Julia Bailey, Josee Dupuis, Corinne Engelman, David Fardo, Jeanine Houwing-Duistermaat, Inke Koenig, Jean MacCluer, Andrew Patterson, and Michael Province. Since 1982, GAW has been funded by the National Institute of General Medical Sciences (NIGMS), through grant R01 GM31575 to Jean MacCluer and Laura Almasy. This grant also provided scholarship funds to assist graduate students and postdoctoral trainees attending GAW20. We would like to recognize Donna Krasnewich for her ongoing support and for her efforts as program director for the GAW grant at the time of GAW20. These proceedings, as well as the continued work of statistical genetic methods development through the collaborative format of the GAWs, would not be possible without her support or that of NIGMS. We are particularly grateful to Jean MacCluer, without her there would be no GAW. As always, we wish to express our gratitude to the GAW participants, whose ongoing, enthusiastic support and vigorous scientific discussions are the very foundations of the Workshop.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | R01 HL104135, K01 HL136700, R01 HL091357 |
| National Institute of General Medical Sciences | GAW20, R01 GM031575 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology