GDNF (including Nurturin)

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Clinical trials testing the trophic factors GDNF and NTRN for the treatment of Parkinson's disease have had mixed results. Analysis of the differences between the successful and unsuccessful trials strongly suggests that efficacious therapeutic approaches require controlled, site-specific delivery of trophic factors using methodology to optimize target tissue distribution.

Original languageEnglish
Title of host publicationEncyclopedia of Movement Disorders
Pages534-537
Number of pages4
ISBN (Electronic)9780123741059
DOIs
StatePublished - Jan 1 2010

Keywords

  • AAV2-neurturin
  • Clinical trial
  • GDNF
  • Neuroprotection
  • Neurorestoration
  • Neurturin
  • Parkinson's disease
  • Putamen
  • Substantia nigra

ASJC Scopus subject areas

  • Medicine (all)
  • Neuroscience (all)

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