GDNF (including Nurturin)

D. M. Gash; G. A. Gerhardt; John T. Slevin

doi:10.1016/B978-0-12-374105-9.00244-6

GDNF (including Nurturin)

D. M. Gash, G. A. Gerhardt, John T. Slevin

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Clinical trials testing the trophic factors GDNF and NTRN for the treatment of Parkinson’s disease have had mixed results. Analysis of the differences between the successful and unsuccessful trials strongly suggests that efficacious therapeutic approaches require controlled, site-specific delivery of trophic factors using methodology to optimize target tissue distribution.

Original language	English
Title of host publication	Encyclopedia of Movement Disorders, Three-Volume Set
Pages	V1-534-V1-537
ISBN (Electronic)	9780123741059
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00244-6
State	Published - Jan 1 2010

Bibliographical note

Publisher Copyright:
© 2010 Elsevier Ltd. All rights reserved.

Keywords

AAV2-neurturin
Clinical trial
GDNF
Neuroprotection
Neurorestoration
Neurturin
Parkinson’s disease
Putamen
Substantia nigra

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1016/B978-0-12-374105-9.00244-6

Cite this

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KW - Putamen

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GDNF (including Nurturin)

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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