Gender-Specific Considerations in Pulmonary Hypertesion

Gerald Supinski, Leigh Ann Callahan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Pulmonary hypertension is an important clinical condition that can progress rapidly, leading to severe disability and death. This chapter reviews the differential diagnosis of pulmonary hypertension, outlining the various conditions that can be associated with this disorder. Many patients with this disorder have secondary pulmonary hypertension, in which the condition is directly linked to disorders that increase pulmonary artery pressures by a well understood pathophysiologic mechanism. However, a substantial number of patients have idiopathic forms of pulmonary hypertension. After initial recognition of the presence of this disorder, the clinician must perform a series of evaluations to differentiate the primary, idiopathic form of this disorder from pulmonary hypertension, which is secondary to disease processes that produce pulmonary hypertension by known pathophysiologic mechanisms. Once adequately categorized, patients must be started on therapeutic regimens that are appropriate for their conditions. Primary pulmonary hypertension demonstrates marked gender predominance, with approximately twice as many woman affected as men. Paradoxically, some data suggest that secondary forms of pulmonary hypertension may affect men more than women. This chapter also describes the symptoms, evaluation, and treatment of patients with the idiopathic pulmonary hypertension syndrome.

Original languageEnglish
Title of host publicationPrinciples of Gender-Specific Medicine
Number of pages15
StatePublished - May 2007

Bibliographical note

Copyright 2021 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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