Gene expression in the third dimension: The ECM-nucleus connection

Virginia A. Spencer; Ren Xu; Mina J. Bissell

doi:10.1007/s10911-010-9163-3

Gene expression in the third dimension: The ECM-nucleus connection

Virginia A. Spencer
, Ren Xu
, Mina J. Bissell

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue-specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.

Original language	English
Pages (from-to)	65-71
Number of pages	7
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	15
Issue number	1
DOIs	https://doi.org/10.1007/s10911-010-9163-3
State	Published - Mar 2010

Bibliographical note

Funding Information:
Acknowledgements We thank Rana Mroue and Joni Mott for their constructive comments in the writing of this manuscript. This work was supported by grants from the U.S. Department of Energy, the Office of Biological and Environmental Research (contract no. DE-AC02-05CH1123), a Low Dose Radiation Program and a Distinguished Fellow Award from the Office of Health and Environmental Research Health Effects Division (contract no. 03-76SF00098) to MJB, the National Cancer Institute (awards R01CA064786, U54CA126552 and U54CA112970 to MJB and R01CA057621 to MJB and Zena Werb), the U.S. Department of Defense Medical and Materiel Command innovator award (contract no.W81XWH0810736 and W81XWH0510338) to MJB, and postdoctoral fellowships W81XWH0410581 to V.A.S and DAMD17-02-1-0441 to R.X., and a post-doctoral fellowship to V.A.S. from the Canadian Institutes of Health Research.

Funding

Acknowledgements We thank Rana Mroue and Joni Mott for their constructive comments in the writing of this manuscript. This work was supported by grants from the U.S. Department of Energy, the Office of Biological and Environmental Research (contract no. DE-AC02-05CH1123), a Low Dose Radiation Program and a Distinguished Fellow Award from the Office of Health and Environmental Research Health Effects Division (contract no. 03-76SF00098) to MJB, the National Cancer Institute (awards R01CA064786, U54CA126552 and U54CA112970 to MJB and R01CA057621 to MJB and Zena Werb), the U.S. Department of Defense Medical and Materiel Command innovator award (contract no.W81XWH0810736 and W81XWH0510338) to MJB, and postdoctoral fellowships W81XWH0410581 to V.A.S and DAMD17-02-1-0441 to R.X., and a post-doctoral fellowship to V.A.S. from the Canadian Institutes of Health Research.

Funders	Funder number
Office of Biological and Environmental Research	DE-AC02-05CH1123
Michigan State University-U.S. Department of Energy (MSU-DOE) Plant Research Laboratory
National Childhood Cancer Registry – National Cancer Institute	R01CA057621, R01CA064786, U54CA112970, U54CA126552
Research Foundation for Health and Environmental Effects	03-76SF00098
U.S. Army Materiel Command	no.W81XWH0810736, W81XWH0510338, W81XWH0410581, DAMD17-02-1-0441
Canadian Institutes of Health Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Extracellular matrix
Gene expression
Nuclear structure

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10911-010-9163-3

Cite this

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abstract = "Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue-specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.",

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N2 - Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue-specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.

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Gene expression in the third dimension: The ECM-nucleus connection

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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