Generation of microparticles using CO2 and CO2-philic antisolvents

Marazban Sarkari, Inaas Darrat, Barbara L. Knutson

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Precipitation using a compressed antisolvent (PCA) is a demonstrated technology for generation of monodisperse ultrafine particles. Microparticle precipitation using CO2-philic antisolvents was studied with the ultimate goal of developing fundamental approaches to tailor microparticle generation. The ability to micronize small solutes and polymeric systems using CO2-philic liquid antisolvents is compared to precipitation with compressed CO2 and traditional antisolvents. Analogies are made between PCA and CO2-philic antisolvent precipitation based on thermodynamic driving forces and the dynamics of the spray process. Analysis of the interfacial gradient energies of the miscible solvent - antisolvent systems indicates that the spray process is dominated by turbulent mixing and not atomization. The similar microparticle morphologies of amorphous and semicrystalline poly(lactic acid) (PLA) obtained using liquid CO2-philic antisolvents and compressed CO2 suggest that a similar demixing mechanism dominates microparticle formation at these operating conditions.

Original languageEnglish
Pages (from-to)1850-1859
Number of pages10
JournalAICHE Journal
Issue number9
StatePublished - 2000

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • General Chemical Engineering


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