Genes and environment in neonatal intraventricular hemorrhage

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31 Scopus citations

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original languageEnglish
Pages (from-to)592-603
Number of pages12
JournalSeminars in Perinatology
Volume39
Issue number8
DOIs
StatePublished - Dec 2015

Bibliographical note

Funding Information:
The Gene Targets for IVH Study Group was supported by NIH NS053865. Dr. Zhang was partially supported by NIH R01 DA016750-09.

Funding Information:
The National Institutes of Health, United States (General Clinical Research Center grants M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587, UL1 RR24979 ) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States (Grants U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689, and U10 HD53109 ) provided grant support for the Neonatal Research Networkʼs Genomics Study. In addition, Dr. Murray received assistance for the GENEVA study from the National Human Genome Research Institute, United States ( U01 HG4423 ) and Dr. Aden received support from Swedish Medical Research Council ( 523-2011-3981, 2009-4250, and 523-2009-7054 ), the regional agreement on medical training and clinical research (ALF 20140316) between Stockholm County Council and the Karolinska Institutet, the Marianne and Marcus Wallenberg foundation ( MMW 2011.0085 ), and the Swedish Brain Foundation ( FP2014-0135 ). The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study.

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

  • GWAS
  • Genes
  • Intraventricular hemorrhage
  • Neonate
  • Preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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