TY - JOUR
T1 - Genes and environmental exposures in veterans with amyotrophic lateral sclerosis
T2 - The GENEVA study: Rationale, study design and demographic characteristics
AU - Schmidt, Silke
AU - Allen, Kelli D.
AU - Loiacono, Valerie T.
AU - Norman, Barbara
AU - Stanwyck, Catherine L.
AU - Nord, Kristina M.
AU - Williams, Christina D.
AU - Kasarskis, Edward J.
AU - Kamel, Freya
AU - McGuire, Valerie
AU - Nelson, Lorene M.
AU - Oddone, Eugene Z.
AU - Bedlack, Richard S.
AU - Morgenlander, Joel C.
AU - Rozear, Marvin P.
AU - Sabet, Arman
AU - Sams, Laura
PY - 2008/5
Y1 - 2008/5
N2 - Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990-1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date.
AB - Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990-1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date.
KW - Amyotrophic lateral sclerosis, case-control study
KW - GENEVA study recruitment methods
KW - Gene-environment interaction
UR - http://www.scopus.com/inward/record.url?scp=43949122951&partnerID=8YFLogxK
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U2 - 10.1159/000126911
DO - 10.1159/000126911
M3 - Article
C2 - 18421219
AN - SCOPUS:43949122951
SN - 0251-5350
VL - 30
SP - 191
EP - 204
JO - Neuroepidemiology
JF - Neuroepidemiology
IS - 3
ER -