Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation

Joshua C. Gray, James MacKillop, Jessica Weafer, Kyle M. Hernandez, Jianjun Gao, Abraham A. Palmer, Harriet de Wit

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Impulsive personality traits are heritable risk factors and putative endophenotypes for addiction and other psychiatric disorders involving disinhibition. This study examined the genetic basis of impulsive personality traits, defined as scores on the Barratt Impulsiveness Scale (BIS-11) and the UPPS-P Impulsive Behavior Scale (UPPS-P). In 983 healthy young adults of European ancestry, the study examined genetic variation in relation to a combined phenotype of seven subscales based on high phenotypic intercorrelations. The study first tested 14 a priori loci that have previously been associated impulsive personality traits or closely related constructs. Second, the study included an exploratory genome-wide scan (i.e., GWAS), acknowledging that only relatively large effects would be detectable in a sample size of ~ 1000. A priori SNP analyses revealed a significant association between the combined impulsivity phenotype and two SNPs within the 5-HT2a receptor gene (HTR2A; rs6313 and rs6311). Follow-up analyses suggested that the effects were specific to the Motor and Non-planning subscales on the BIS-11, and also that the two loci were in linkage disequilibrium. The GWAS yielded no statistically significant findings. This study further implicates loci within HTR2A with certain forms of self-reported impulsivity and identifies candidates for future investigation from the genome-wide analyses.

Original languageEnglish
Pages (from-to)398-404
Number of pages7
JournalPsychiatry Research
Volume259
DOIs
StatePublished - Jan 2018

Bibliographical note

Funding Information:
Funding for this study was provided by NIH Grant R01DA032015 . JM is the holder of the Peter Boris Chair in Addictions Research, which partially supported his role.

Publisher Copyright:
© 2017

Keywords

  • Endophenotype
  • Genetics
  • Impulsivity
  • Personality traits
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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