TY - JOUR
T1 - Genetic and antigenic analysis of the influenza virus responsible for the 1992 Hong Kong equine influenza epizootic
AU - Lai, Alexander C.K.
AU - Lin, Yi Pu
AU - Powell, David G.
AU - Shortridge, Kennedy F.
AU - Webster, Robert G.
AU - Daly, Janet
AU - Chambers, Thomas M.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1994/11/1
Y1 - 1994/11/1
N2 - An outbreak of influenza occurred among thoroughbred racehorses in Hong Kong in November-December 1992, with morbidity of 37%. All horses involved had been vaccinated against equine-1 and equine influenza viruses but not against the virus responsible for the 1989 equine influenza outbreak in northern China (influenza A/equine/Jilin/89, subtype H3N8). Therefore the source and nature of the virus causing the Hong Kong outbreak was investigated. Virus isolated from a horse infected during the outbreak was used for genetic analysis. All the viral gene segments were similar to those of equine-2 (H3N8) influenza viruses and unrelated to those of equine/Jilin/89 virus. The nucleotide sequence of the viral hemagglutinin gene showed high homology (99.4%) to that of influenza A/equine/Suffolk/89 (H3N8) virus which has circulated extensively in Europe. However, these viruses differed in their antigenic reactivity to a panel of monoclonal antibodies. Preliminary epizootiological information plus the concordance of amino acid sequence between hemagglutinins of the Hong Kong isolate and a contemporaneous equine-e influenza virus isolate from the United Kingdom indicated that the probable source of the Hong Kong outbreak was horses recently imported from England or Ireland.
AB - An outbreak of influenza occurred among thoroughbred racehorses in Hong Kong in November-December 1992, with morbidity of 37%. All horses involved had been vaccinated against equine-1 and equine influenza viruses but not against the virus responsible for the 1989 equine influenza outbreak in northern China (influenza A/equine/Jilin/89, subtype H3N8). Therefore the source and nature of the virus causing the Hong Kong outbreak was investigated. Virus isolated from a horse infected during the outbreak was used for genetic analysis. All the viral gene segments were similar to those of equine-2 (H3N8) influenza viruses and unrelated to those of equine/Jilin/89 virus. The nucleotide sequence of the viral hemagglutinin gene showed high homology (99.4%) to that of influenza A/equine/Suffolk/89 (H3N8) virus which has circulated extensively in Europe. However, these viruses differed in their antigenic reactivity to a panel of monoclonal antibodies. Preliminary epizootiological information plus the concordance of amino acid sequence between hemagglutinins of the Hong Kong isolate and a contemporaneous equine-e influenza virus isolate from the United Kingdom indicated that the probable source of the Hong Kong outbreak was horses recently imported from England or Ireland.
UR - http://www.scopus.com/inward/record.url?scp=0027995481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027995481&partnerID=8YFLogxK
U2 - 10.1006/viro.1994.1583
DO - 10.1006/viro.1994.1583
M3 - Article
C2 - 7941336
AN - SCOPUS:0027995481
SN - 0042-6822
VL - 204
SP - 673
EP - 679
JO - Virology
JF - Virology
IS - 2
M1 - 71583
ER -