Abstract
Genetic and environmental interactions determine cancer risks but some cancer incidence is primarily a result of inherited genetic deficits alone. Most cancers have an occupational, viral, nutritional, behavioral or iatrogenic etiology. Cancer can sometimes be controlled through broad public health interventions including industrial hygiene and engineering controls. Chromium and nickel are two human carcinogens associated with industrial exposures where public health measures apparently work. Carcinogenic mechanisms of these metals are examined by electron-spin-resonance-spectroscopy and somatic-mutation-and-recombination in Drosophila melanogaster in this report. Both metals primarily affect initiation processes in cancer development suggesting important theoretical approaches to prevention and followup.
| Original language | English |
|---|---|
| Pages (from-to) | 181-194 |
| Number of pages | 14 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 255 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 2004 |
Funding
1National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC; 2Department of Biological Sciences, Illinois State University, Normal, IL;3Office of Prevention, Pesticides and Toxic Substances, US Environmental Protection Agency, Washington, DC; 4Office of Science and Technology, Office of Water, US Environmental Protection Agency, Washington, DC; 5Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA Address for offprints: A. Chiu, National Center for Environment Assessment, Office of Research and Development, RF8623D, U.S. Environmental Protec- Disclaimer: The opinions and conclusions expressed in this paper are those of the authors and do not necessarily reflect those of the National Center for Environmental Assessment, Office of Research and Development, Office of Prevention, Pesticides and Toxic Substances, Office of Science and Technology, Office of Water, of the US Environmental Protection Agency; the Department of Biological Sciences, Illinois State University; or the Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health.
| Funders | Funder number |
|---|---|
| U.S. Environmental Protection Agency | |
| National Institute for Occupational Safety and Health | |
| VA Office of Research and Development | |
| Office of Water | |
| National Center For Environmental Assessment | |
| VA Office of Research and Development | |
| Office of Science and Technology | |
| Illinois State University | |
| U.S. Environmental Protection Agency | |
| National Institute for Occupational Safety and Health | |
| National Center For Environmental Assessment | |
| Department of Biological Sciences, Dartmouth College | |
| VA Office of Research and Development | |
| Office of Water | |
| Office of Juvenile Justice and Delinquency Prevention |
Keywords
- Chromium
- Drosophila
- Electron spin resonance
- Epidemiology
- Industrial carcinogens
- Lung cancer
- Nickel
- Oncogenes
- Physiologic mechanisms
- Somatic recombination
- Valency states
- Wing spot assay
ASJC Scopus subject areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
