TY - JOUR
T1 - Genetic control of stem-cell properties and stem cells in aging
AU - Liang, Ying
AU - Van Zant, Gary
PY - 2003/5
Y1 - 2003/5
N2 - Studies to uncover genes regulating stem cells usually adopt one of two distinct lines of investigation: forward genetics and reverse genetics approaches. The forward genetics approach proceeds from measurable phenotypic differences to genetic polymorphism and, as the name implies, the path of investigation is reversed using reverse genetics. The number of newly discovered loci responsible for stem cell-specific phenotypes and functioning is increasing at a rapid rate owing to the success of both approaches. These loci regulate stem cells by intrinsic (cell autonomous) and/or extrinsic mechanisms and dictate stem-cell fate decisions. During the aging process, stem cells undergo both quantitative and qualitative changes, which are hypothesized to affect both the rate of aging and the longevity of an organism.
AB - Studies to uncover genes regulating stem cells usually adopt one of two distinct lines of investigation: forward genetics and reverse genetics approaches. The forward genetics approach proceeds from measurable phenotypic differences to genetic polymorphism and, as the name implies, the path of investigation is reversed using reverse genetics. The number of newly discovered loci responsible for stem cell-specific phenotypes and functioning is increasing at a rapid rate owing to the success of both approaches. These loci regulate stem cells by intrinsic (cell autonomous) and/or extrinsic mechanisms and dictate stem-cell fate decisions. During the aging process, stem cells undergo both quantitative and qualitative changes, which are hypothesized to affect both the rate of aging and the longevity of an organism.
KW - Aging
KW - Genetics
KW - Longevity
KW - Quantitative trait loci
KW - Stem cells
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U2 - 10.1097/00062752-200305000-00001
DO - 10.1097/00062752-200305000-00001
M3 - Review article
C2 - 12690286
AN - SCOPUS:0037623474
SN - 1065-6251
VL - 10
SP - 195
EP - 202
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
IS - 3
ER -