Genetic dissection of disease resistance to the blue mold pathogen, peronospora Tabacina, in Tobacco

Xia Wu, Dandan Li, Yinguang Bao, David Zaitlin, Robert Miller, Shengming Yang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Tobacco blue mold, caused by the obligately biotrophic oomycete pathogen Peronospora tabacina D.B. Adam, is a major foliar disease that results in significant losses in tobacco-growing areas. Natural resistance to P. tabacina has not been identified in any variety of common tobacco. Complete resistance, conferred by RBM1, was found in N. debneyi and was transferred into cultivated tobacco by crossing. In the present study, we characterized the RBM1-mediated resistance to blue mold in tobacco and show that the hypersensitive response (HR) plays an important role in the host defense reactions. Genetic mapping indicated that the disease resistance gene locus resides on chromosome 7. The genetic markers linked to this gene and the genetic map we generated will not only benefit tobacco breeders for variety improvement but will also facilitate the positional cloning of RBM1 for biologists.

Original languageEnglish
Pages (from-to)555-568
Number of pages14
Issue number4
StatePublished - Dec 1 2015

Bibliographical note

Funding Information:
We thank James T. Hall for maintaining the blue mold pathogen and for his help with plant inoculations. We are grateful to the Kentucky Tobacco Research & Development Center (KTRDC) for providing facilities and growth chamber. This work was supported by British American Tobacco (to Shengming Yang).

Publisher Copyright:
© 2015 by the authors.


  • Blue mold
  • Disease resistance
  • Genetic marker
  • Tobacco

ASJC Scopus subject areas

  • Agronomy and Crop Science


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