TY - JOUR
T1 - Genetic mapping of prm-1, igl-1, smst, mtv-6, sod-1, and ets-2 and localization of the down syndrome region on mouse chromosome 16
AU - Reeves, R. H.
AU - Gallahan, D.
AU - O’Hara, B. F.
AU - Callahan, R.
AU - Gearhart, J. D.
PY - 1987
Y1 - 1987
N2 - Molecular probes were used as markers in the backcross (Czech II × BALB/cPt) × Czech II to determine the positions of six genes on mouse chromosome 16 (MMU 16). The order of the genes mapped is (centromere), protamine-1 (Prm-1), immunoglobulin λ1 light chain (Igl-l), preprosomatostatin (Smst), an endogenous mouse mammary tumor virus locus (Mtv-6), and two more distal sequences, superoxide dis-mutase, cytoplasmic form (Sod-1), and the proto-oncogene sequence Ets-2. The largest recombination frequency between any two adjacent markers is 24 cM, and thus the position of any marker on MMU 16 that is polymorphic between these two strains can be readily determined in this backcross. A region of MMU 16 which corresponds to the Down syndrome region of human chromosome 21 is located near the distal end of the chromosome.
AB - Molecular probes were used as markers in the backcross (Czech II × BALB/cPt) × Czech II to determine the positions of six genes on mouse chromosome 16 (MMU 16). The order of the genes mapped is (centromere), protamine-1 (Prm-1), immunoglobulin λ1 light chain (Igl-l), preprosomatostatin (Smst), an endogenous mouse mammary tumor virus locus (Mtv-6), and two more distal sequences, superoxide dis-mutase, cytoplasmic form (Sod-1), and the proto-oncogene sequence Ets-2. The largest recombination frequency between any two adjacent markers is 24 cM, and thus the position of any marker on MMU 16 that is polymorphic between these two strains can be readily determined in this backcross. A region of MMU 16 which corresponds to the Down syndrome region of human chromosome 21 is located near the distal end of the chromosome.
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U2 - 10.1159/000132347
DO - 10.1159/000132347
M3 - Article
C2 - 2882955
AN - SCOPUS:0023202733
SN - 0301-0171
VL - 44
SP - 76
EP - 81
JO - Cytogenetics and Cell Genetics
JF - Cytogenetics and Cell Genetics
IS - 2-3
ER -